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Although the sedative effect of antihistamines are sometimes desired, like in a patient with allergic rhinitis who is having difficulty sleeping, generally the use of these drugs should be limited in a person who is driving or operating heavy machinery.Some of the first generation antihistamines also block other receptors like cholinergic (muscarinic) receptors and alpha adrenergic receptors.

We had a few concerned parents asking us which antihistamines are more likely to affect their children's behaviour, so we decided to break it down.

H2 blockers (eg, ranitidine, famotidine) commonly are used for the treatment of heartburn and gastroesophageal reflux disease.

These medications decrease gastric acid secretion in the stomach by antagonizing the effects of histamine at H2 receptors found in gastrointestinal parietal cells.

Antihistamines aren't only used for allergies, however.

Some are more commonly used to treat nausea and vomiting, such as Cyclizine (the main ingredient in Valoid), while others are prescribed to patients battling with insomnia, or as an appetite stimulant.

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